Antigenic identity of immunodominant proteins of <i>Bacillus anthracis</i> genovariants

Introduction. The main biological raw materials for the production of immunobiological preparations identification Bacillus anthracis are its specific antigens, protective antigen and EA1 protein.
 Purpose. To determine antigenic identity immunodominant proteins different genovariants B. isolated by gel chromatography electrophoresis.
 Materials methods. Culture filtrates isogenic variants strain 575/122 (pXO1+, pXO2+): R01 pXO2); R00 (pXO1, pXO2) were used in study. Gel chromatographic fractionation electrophoretic separation carried out according to standard properties electrophoresis studied immunodiffusion with polyclonal monospecific sera against protein S-layer.
 Results. culture pXO2)yielded fractions 1 5. Sera antigens fraction strains identified identical antigens. Serum 5 contained antibodies numerous proteins, including Discussion. was identified.
 Conclusion. PA can be monoclonal suitable design diagnostic preparations.